本文报道康乐液的致突变和致畸胎性研究。在有无大鼠肝微粒体酶代谢活化条件下,经Amcs法的TA97、TA98、TA100和TA102菌株行点试验和平皿掺入试验,小鼠骨髓嗜多染红细胞微核试验、人外周血淋巴细胞姐妹染色单体互换试验、小鼠精子畸形和小鼠致畸试验表明:康乐液未显示致突变性,对小鼠胚胎、骨骼和内脏亦无致畸作用。 This article reports the research on the mutagenesis and teratogenicity of Kangle liquid. In the presence or absence of rat liver microsomal enzyme metabolic activation conditions, the Amcs method of TA97, TA98, TA100 and TA102 strains point-line test and plate incorporation test, mouse bone marrow polychromatic erythrocyte micronucleus test, human peripheral blood lymph Sister chromatid exchange experiments, mouse sperm deformity and mouse teratogenicity test showed that: Kang Le liquid did not show mutagenicity, the mouse embryo, bone and internal organs also teratogenic effect.