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1,2,3-三氮唑芳香寡聚体可以通过分子内三中心C—H···O氢键诱导形成折叠或螺旋二级结构.通过~1H NMR实验研究这类人工二级结构在氯仿和二氯甲烷中进一步形成分子间C—H···Cl~-和C—H···N氢键的倾向性,发现分子内的两类C—H···O氢键可以通过进一步形成C—H···Cl~-氢键而被弱化.在过量Cl~-存在时,三氮唑N-1侧的六元环C—H···O氢键被显著破坏,由此形成分子间C—H···Cl~-氢键,从而诱导骨架形成另一类更加扩展的折叠构象.过量的Br~-和I~-也可以形成类似的分子间氢键.对其中一个八聚体研究揭示,1,2,3-三氮唑螺旋体的内侧2,3-位N原子还可以与三炔和二炔衍生物的炔基C—H形成分子间弱的C—H···N氢键,三氮唑折叠结构通过诱导N原子形成环形定位促进这一分子间弱氢键产生协同效应.
The 1,2,3-triazole azulenes can be induced to form folded or helical secondary structures through intramolecular C-H · O hydrogen bonding. The ~ 1H NMR experiments were performed on Chloroform and methylene chloride to further form intermolecular C-H · Cl ~ - and C-H ··· N hydrogen bonds and found that intramolecular two types of C-H · O hydrogen bonds can be passed Further forming C-H ··· Cl ~ - hydrogen bonds are weakened in the presence of excess Cl ~ -, triazole nitrogen side of the six-membered ring C-H ··· O hydrogen bonds were significantly damaged by This forms intermolecular C-H ··· Cl ~ -hydrogen bonds, inducing the skeleton to form another more expanded folded conformation. Excess Br ~ - and I ~ ~ can also form similar intermolecular hydrogen bonds, An octamer study revealed that the inner 2,3-position N atom of 1,2,3-triazospirin can also form a weak intermolecular C-H with the alkynyl C-H of the trialkyne and diacetylene derivatives ···················································································································································································································································································································································.