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目的:观察雷米普利联合厄贝沙坦治疗老年人早期糖尿病肾病的疗效。方法:52例早期糖尿病肾病老年患者随机分成两组,对照组单用厄贝沙坦,治疗组联用雷米普利,共12周。比较两组治疗前后24 h尿微量白蛋白、内生肌酐清除率、血钾及血压的变化。结果:治疗组24h尿微量白蛋白较对照组显著下降(P<0.01)。两组内生肌酐清除率及血钾无明显变化(P>0.05)。结论:雷米普利和厄贝沙坦联用,可有效减少早期糖尿病肾病老年患者尿白蛋白排出。
Objective: To observe the efficacy of ramipril combined with irbesartan in the treatment of early diabetic nephropathy in the elderly. Methods: 52 elderly patients with early diabetic nephropathy were randomly divided into two groups. The control group received irbesartan alone. The treatment group received ramipril for 12 weeks. The urinary albumin, endogenous creatinine clearance, serum potassium and blood pressure were compared between the two groups before and after treatment. Results: 24h urine microalbuminuria in the treatment group was significantly lower than that in the control group (P <0.01). Endogenous creatinine clearance rate and serum potassium did not change significantly between the two groups (P> 0.05). Conclusion: The combination of ramipril and irbesartan can effectively reduce urinary albumin excretion in elderly patients with early diabetic nephropathy.