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目的 研究血清脂蛋白a[lipoprotein(a) ,LP(a) ]在脑梗死形成中的作用及意义。 方法 采用双抗体夹心法检测血清中LP(a)的浓度。结果 与动脉粥样硬化有关的脑梗死 (atherothromboticbraininfarc tion ,ABI)组 (n =6 2 )LP(a)浓度显著高于对照组 (n =37)及脑栓塞组 (n =15 ) (P <0 .0 5 )。ABI组、脑栓塞组及对照组中不同性别及不同年龄的LP(a)水平无显著差异 (P >0 .0 5 )。脑梗死组在有无糖尿病患者中 ,LP(a)水平无显著差异 (P >0 .0 5 )。结论 LP(a)是与遗传有关的血浆脂蛋白 ,通过血清LP(a)的水平的测定 ,一方面可作为脑血栓形成和脑栓塞的鉴别 ;另一方面对于有缺血性脑卒中发生倾向者 ,可推断其患病风险 ,也可作为脑卒中预测的一个指标 ,对于已经发生脑梗死的患者 ,可推断其再发生的可能性。
Objective To study the role and significance of serum lipoprotein (a), LP (a) in the development of cerebral infarction. Methods Serum LP (a) concentration was detected by double antibody sandwich method. Results Compared with control group (n = 37) and cerebral embolism group (n = 15), the concentration of LP (a) in atherothrombotic cerebral infarction group (n = 6 2) 0 .0 5). There was no significant difference in LP (a) level between ABI group, cerebral embolism group and control group at different genders and ages (P> 0.05). There was no significant difference in LP (a) level between patients with cerebral infarction and without diabetes (P> 0.05). Conclusions LP (a) is a genetically related plasma lipoprotein that can be used as a marker of cerebral thrombosis and cerebral embolism through the determination of serum LP (a) levels. On the other hand, LP (a) , Can be inferred that the risk of illness, but also as an indicator of stroke prediction, for patients with cerebral infarction has been inferred the possibility of its recurrence.