治疗慢性乙肝一般有两种可行途径:一种是增强免疫系统以清除感染的肝细胞,常用药物有α-干扰素、治疗性疫苗等;另一种是抑制病毒复制,常用药物有核苷类似物等。 通过免疫调节而发挥作用的药物常常能显著增强免疫系统,致使感染的肝细胞坏死,所以患者必须有很强的肝细胞再造能力,才能及时代替受损的肝细胞。这也是干扰素和治疗性疫苗有可能导致原本己有肝硬化的患者发生肝代偿失调的原因。 There are generally two possible ways to treat chronic hepatitis B. One is to strengthen the immune system to remove infected liver cells, commonly used drugs are interferon-alpha, therapeutic vaccines and the like; the other is to inhibit virus replication, commonly used drugs are similar to nucleosides And so on. Medications that act by immunomodulation often significantly enhance the immune system and cause necrosis of infected hepatocytes, so patients must have strong hepatocyte recycling skills to replace damaged liver cells in time. This is why interferons and therapeutic vaccines may cause liver decompensation in patients with already existing cirrhosis.