机体内乙酰化反应常为机体内源性物质,如5-羟色胺、组胶等某些氨基酸以及外源性物质羧酸、氨基水杨酸、对氨基苯甲酸、磺胺和普鲁卡因酰胺等药物的代谢途径。60年代以来,逐步发现药物在体内的乙酰化有两种表型,一类以异烟肼为代表,包括异烟肼、肼苯哒嗪、磺胺二甲嘧啶、氨苯砜等,其乙酰化速率在个体间差别较大,在人群中 Acetylation of the body is often the body’s endogenous substances, such as 5-hydroxytryptamine, gel and some other amino acids and exogenous substances carboxylic acid, aminosalicylic acid, p-aminobenzoic acid, sulfonamide and procainamide The metabolic pathway of the drug. Since the 1960s, two phenotypes of acetylation of drugs have been gradually discovered in the body. One type is represented by isoniazid, including isoniazid, hydralazine, sulfamethazine, dapsone and the like, and its acetylation Rates vary widely among individuals in the population