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我们对本地区苗族人群糖尿病肾病(DN)的遗传流行病学进行调查,并用PCR检测出其基因多态性,且与汉族人群中DN患者进行对照。旨在探讨本地区不同族类人群中血管紧张素转换酶(ACE)基因的插入、缺失(I/D)多态性与DN的发病关系。 一、材料与方法 1.对象选择:选自经我院确诊的DN患者。调查其中68例苗族患者家系及其中一、二级亲属,共1262人。 2.群体患病率:对湖南西部及毗邻地区进行DN普查。苗族人群中3486人
We investigated the genetic epidemiology of diabetic nephropathy (DN) in Miao people in our region and detected the genetic polymorphism by PCR and compared them with DN patients in Han population. The aim of this study is to investigate the relationship between the insertion and deletion of angiotensin converting enzyme (ACE) gene and the pathogenesis of DN in different ethnic groups in this area. First, the material and method 1. Object selection: selected from DN patients diagnosed by our hospital. A total of 1262 people were investigated in 68 Miao families and their first and second degree relatives. 2. The prevalence of groups: DN survey of western Hunan and adjacent areas. 3486 Miao people