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质子泵抑制剂(PPI)是目前治疗酸相关性疾病的首选药物,近年来有关其所致不良反应及潜在用药风险引起关注。除短期用药引起腹泻、头痛、恶心和皮疹等不良反应,以及长期使用增加感染风险,引起营养缺乏等相关疾病外,国外近期陆续有报道PPI相关亚急性皮肤型红斑狼疮(SCLE),国内尚未见相关报道。本文结合国外文献综述PPI相关SCLE的临床特点及其预防与治疗措施等,以提高临床用药安全性。
Proton pump inhibitors (PPIs) are currently the first choice for the treatment of acid-related diseases. In recent years, attention has been paid to the adverse reactions caused by them and the risks of potential drug use. In addition to short-term medication caused by diarrhea, headache, nausea and rash and other adverse reactions, as well as long-term use to increase the risk of infection, causing nutritional deficiencies and other related diseases, the recent overseas have reported PPI-related subacute cutaneous lupus erythematosus (SCLE) Related reports. In this paper, foreign literature review of PPI-related SCLE clinical features and prevention and treatment measures to improve the safety of clinical medication.