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目的 :(1)观察耐力运动和补充外源性NO前体L -Arg(左旋精氨酸 )对机体各组织NO生成能力的影响 ;(2 )观察补充外源性NO前体L -Arg对机体运动疲劳状况的影响。方法 :将 30只SD大鼠随机分成安静组、运动对照组和运动用药组 ,运动组大鼠进行 4周跑台耐力训练和一次力竭运动 ,其中运动用药组每天给予 4 0mg每kg体重L -Arg灌胃 ,测定了力竭运动后即刻大鼠组织NO生成能力以及血清生化指标的变化。结果 :(1)所有运动组大鼠血清、肌肉、心肌、肝脏NOS活性均有升高趋势 ,尤其以血清、心肌和肝脏的升高具有显著性意义 ;(2 )运动用药组大鼠血清血尿素 (BUrea)、谷丙转氨酶 (ALT)、乳酸脱氢酶 (LDH)均较运动对照组有升高趋势。结论 :(1)补充外源性L -Arg对机体整体生成NO的能力 ,尤其是心脏等器官生成NO的能力可能有促进作用 ;(2 )补充外源性NO前体L -Arg会增加耐力运动中体内自由基损伤作用需进一步研究
Objective: (1) To observe the endurance exercise and exogenous NO precursor L -Arg (L-arginine) on the ability of NO generation in the organization; (2) to observe the exogenous NO precursor L -Arg The impact of body movement fatigue. Methods: Thirty SD rats were randomly divided into quiet group, exercise control group and exercise group. Exercise group rats were subjected to endurance training and exhaustive exercise for 4 weeks. The rats in exercise group were given daily 40 mg / kg body weight of L -Arg gavage to determine the NO generation capacity of rat tissue and the changes of serum biochemical indexes immediately after exhaustive exercise. Results: (1) The activity of NOS in serum, muscle, myocardium and liver increased in all exercise groups, especially in serum, myocardium and liver; (2) BUrea, ALT and LDH increased compared with the control group. Conclusions: (1) Supplementation of exogenous L-Arg may promote NO production in the body as a whole, especially in organs such as the heart; (2) L-Arg, an exogenous NO precursor, may increase endurance Exercise in vivo free radical damage needs further study