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Clark(1977)曾指出,减少羊毛脂的天然游离醇含量并除去其中残存的任何去污剂之后,则对原来的羊毛脂致敏的患者,斑试阳性反应减少97%,对含30%羊毛醇的凡士林起反应的患者,几乎可减少99%。对这一发现,作者作了进一步的试验,以便找出游离醇和去污剂含量的实用限度,确保羊毛脂对患者没有或几乎没有变应原性。作者用标准的医用羊毛脂(无水羊毛脂)按 Cla-rk 等的方法3和方法4,除去其中的游离醇和去污剂残留物。在精制羊毛脂中,分别加入5%、10%、20%和30%(重量)羊毛醇。又在含10%的羊毛醇的羊毛脂中,分别加入0.05%、0.15%和0.30%(重量)的非离子型去污剂(noniodet SH100)。共制得9份标本。用双盲法在三所医院分别作斑试,并设对照组,用
Clark (1977) pointed out that after reducing the natural free alcohol content of lanolin and removing any detergent remaining therein, the positive response to the spot test was reduced by 97% for those patients sensitized with the original lanolin, Alcohol Vaseline-responsive patients, can be reduced by almost 99%. To this discovery, the authors undertook further trials to find practical limits to free alcohol and detergent content, to ensure that lanolin has little or no allergenicity for the patient. The authors used standard medical lanolin (anhydrous lanolin) according to Cla-rk method 3 and method 4, which remove the free alcohol and detergent residues. In refined lanolin, 5%, 10%, 20% and 30% by weight of lanolin were added respectively. Again, 0.05%, 0.15% and 0.30% by weight of noniodet SH100 were added to lanolin containing 10% of lanolin, respectively. A total of 9 samples were obtained. Double-blind method in the three hospitals were spot test, and set the control group, with