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幽门螺杆菌(Helicobacter pylori,H.pylori)感染已被世界卫生组织确定为胃癌危险因素。H.pylori感染引起胃黏膜的炎症,诱导宿主产生多种细胞因子,其中有些因子可导致胃黏膜上皮细胞向癌演变。H.pylori感染后白细胞介素(ILs)表达发生明显改变,不同的ILs在胃癌的发生和发展过程中发挥不同的作用。文章就ILs在胃癌发生和发展中的作用研究进展作一综述。
Helicobacter pylori (H.pylori) infection has been identified by the World Health Organization as a gastric cancer risk factor. H. pylori infection causes inflammation of the gastric mucosa, inducing the host to produce a variety of cytokines, some of which can cause gastric mucosal epithelial cells to evolve to the cancer. After H.pylori infection, the expression of interleukin (ILs) changes significantly, and different ILs play different roles in the occurrence and development of gastric cancer. The article reviews the research progress of the role of ILs in the occurrence and development of gastric cancer.