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肌酸激酶同工酶BB(CK-BB)象癌胚抗原及甲胎蛋白一样,存在于肿瘤或胎儿组织中,它在健康成人组织中含量极微或不存在。作者用放射免疫分析检测了未经治疗的17例前列腺癌患者血清CK-BB,其中15例(占89%)的血清中存在异常量CK-BB。用琼脂糖电泳测定这15例阳性血清,其中9例CK-BB呈阳性,余下6例因血清贮存过久不适用。同时用放射免疫分析检测了转移性前列腺癌缓解期患者血清,CK-BB含量正常。在75例良性前列腺增生患者中仅6例(占8%)血清CK-BB阳性。其他腺癌(如乳腺癌、结肠癌和卵巢癌等)和代谢疾病中血清CK-BB含量增加患者,大多数是疗效不
Creatine kinase isoenzyme BB (CK-BB), like carcinoembryonic antigen and alpha-fetoprotein, is present in tumors or fetal tissues, and it is found in very small amounts or absent in healthy adult tissues. The authors used radioimmunoassay to detect serum CK-BB in 17 untreated prostate cancer patients, of whom 15 (89%) had an abnormal amount of CK-BB. The 15 positive sera were measured by agarose gel electrophoresis. Among them, 9 cases were positive for CK-BB, and the remaining 6 cases were inapplicable because the serum was stored for too long. At the same time, radioimmunoassay was used to detect the serum of patients with metastatic prostate cancer at remission stage, and the content of CK-BB was normal. Of the 75 patients with benign prostatic hyperplasia, only 6 (8%) had serum CK-BB positive. Most patients with other adenocarcinomas (such as breast, colon, and ovarian cancers) and metabolic diseases have increased levels of serum CK-BB