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作者用氯亚铂酸盐和带有正电荷的有机分子作用,制备了铂-染料复合物,希望获得对肿瘤细胞有选择性细胞毒的新一类放射增敏剂,并对Pt-(Rh-123)_2(铂-若丹明;Pt-Rhodamine-123)、Pt027〔Pt-(3,3′-diethyloxatricarbocyanineiodine)〕、PtSA(Pt-Stains all)、Pt Deca(Pt-Dequaliumchloride)进行了放射增敏和抗肿瘤的实验研究。体外放射增敏作用:实验用人头颈部鳞癌细胞株Scc-25和Scc-25/CP,铂复合物的剂量为杀死50～90%细胞所需的药物浓度。对乏氧肿瘤细胞的放射
The authors prepared a platinum-dye complex by the action of chloroplatinates and organic molecules with positive charges, hoping to obtain a new class of radiosensitizers that are selective for cytotoxicity of tumor cells, and for Pt-(Rh -123)_2 (platinum rhodamine; Pt-Rhodamine-123), Pt027 (Pt-(3,3’-diethyloxatricarbocyanineiodine)), PtSA (Pt-Stains all), Pt Deca (Pt-Dequalium chloride) were irradiated Sensitization and anti-tumor experimental studies. In vitro radiosensitization: In experimental human head and neck squamous cell carcinoma cell lines Scc-25 and Scc-25/CP, the dose of the platinum complex is the concentration required to kill 50-90% of the cells. Radiation to hypoxic tumor cells