目的　探讨高碘是否和低碘一样影响学习记忆功能 ,特别是母体高碘是否会对仔代造成影响。方法　用高碘、低碘饮水喂养亲代鼠 3个月 ,用水迷宫实验评价了仔一代鼠 30日龄和 90日龄时的学习记忆功能。结果　 30日龄仔鼠高碘、低碘迷宫所用时间和错误次数均较适碘组显著延长 ;同批鼠 90日龄时 ,无论高碘、低碘还是适碘组 ,迷宫时间、、错误次数均较 30日龄鼠显著减少 ,但 90日龄鼠 3组间差异仍存在显著意义。结论　摄入过量碘和碘缺乏一样 ,可引起后代学习记忆功能障碍 ,此障碍可能是不可逆的 ,并且影响的是记忆过程的开端环节和基础阶段 :即识记过程 ,但对记忆的保持和再认过程无明显影响 Objective To investigate whether high iodine has the same effect on learning and memory as low iodine, especially whether maternal high iodine will affect younger generation. Methods The high-iodine and low-iodine drinking water was used to feed the offspring for 3 months. The water maze test was used to evaluate the learning and memory abilities of the offspring at 30 days and 90 days. Results Compared with iodine group, the time and number of errors of high iodine and low iodine maze of 30-day-old offspring rats were significantly prolonged. Compared with 90-day-old rats of the same group, maze time, error number Compared with the 30-day-old mice, the differences were still significant. Conclusions Excessive intake of iodine and iodine deficiency can cause learning and memory dysfunction in offspring, which may be irreversible and affect the beginning and basic stages of the memory process: the process of memorizing, but the maintenance of memory and then No significant effect of the process