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龋齿在发达国家中是一种十分常见的疾病.近几年来,也许是由于氟化物的使用,使龋齿发病明显减少,但仍是青少年最常见的慢性病之一.本文介绍了龋齿的预防接种,并着重论述用于防龋的抗原及其免疫机理.致龋菌龋齿发生条件:(1)致龋菌:能迅速产酸,使pH<5.5以溶解牙釉质;(2)糖:食物中的糖有利于细菌定居,并可被后者代谢而产酸.一些细菌能使无菌大鼠发生龋齿.在致龋链球博、乳杆菌和放线菌中,似以变形链球菌(以下简称变链菌)的致龋力最强,并与人龋齿有关.近年来龋齿免疫研究大多是用变链菌接种龋齿动物、猴和人进行的.
Dental caries is a very common disease in developed countries. In recent years, the use of fluoride may reduce the incidence of dental caries, but it is still one of the most common chronic diseases in adolescents.This paper introduces the preventive vaccination of dental caries, And focuses on the anti-caries antigens and their immune mechanisms Cariogenic caries occurrence conditions: (1) cariogenic bacteria: can quickly produce acid, so that pH <5.5 to dissolve enamel; (2) sugar: food Sugar is conducive to the colonization of bacteria, and can be metabolized by the latter acid production.Some bacteria can make aseptic rat tooth decay in the carid streptococcus, lactobacillus and actinomycetes, like Streptococcus mutans (hereinafter referred to as variable Streptococcus) is the strongest cariogenic group, and is related to human dental caries.In recent years, dental caries research mostly used carbendazim to inoculate cariogenic animals, monkeys and humans.