论文部分内容阅读
目的研究骨髓增生异常综合征(myelodysplasticsyndrome,MDS)的细胞遗传学、血液学与预后的相互关系。方法采用骨髓直接法和24小时短期培养法制备染色体标本,用R显带技术,对50例MDS进行核型分析。结果50例MDS中,发现有异常核型22例,发生率44.0%(22/50)。异常类型6种2例add(8);4例-7;4例5q-;9例7q-;2例20q-;1例6q-。结论5q-,-7,7q-是MDS中最为常见的染色体核型异常,伴有5q-染色体核型异常的预后较好,而伴有-7,7q-核型异常的预后不良。细胞遗传学在MDS的诊断、病情发展和预后判断中有着至关重要的作用。
Objective To study the relationship between cytogenetics, hematology and prognosis in patients with myelodysplastic syndrome (MDS). Methods Chromosome specimens were prepared by direct bone marrow method and 24-hour short-term culture method. Karyotype analysis was performed on 50 cases of MDS using R-banding technique. Results In 50 cases of MDS, 22 cases were found with abnormal karyotype, the incidence rate was 44.0% (22/50). Abnormal type 6 kinds of 2 cases add (8); 4 cases -7; 4 cases 5q-; 9 cases 7q-; 2 cases 20q-; 1 case 6q-. Conclusion 5q -, - 7, 7q - is the most common chromosomal abnormalities in MDS. The prognosis of patients with 5q - chromosomal abnormalities is better, while the prognosis of patients with abnormalities of -7,7q - karyotypes is poor. Cytogenetics plays a crucial role in the diagnosis, progression and prognosis of MDS.