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最近,在某些类型的恶性肿瘤患者血清中发现数种非典型肌酸激酶(非典型CK)。多数非典型CK是大分子物质,并可按电泳迁移率的不同将其分为两类,一类在CK-MM的阳极一侧,另一类在阴极一侧。前者主要是细胞液CK同工酶与免疫球蛋白的复合物;后者因其电泳迁移率与线粒体CK相同被认为是线粒体CK。其相对分子量、热稳定性等与已研究过的线粒体CK则不尽相同。为弄清这种电泳迁移于CK-MM阴极一侧CK的来源,作者研究了心、肝组织的线粒体CK,对
Recently, several atypical creatine kinases (atypical CK) have been found in the serum of certain types of cancer patients. Most atypical CKs are macromolecular substances and can be classified into two categories according to their electrophoretic mobility, one on the anode side of CK-MM and the other on the cathode side. The former is mainly a complex of cytoskeletal CK isoenzyme and immunoglobulin; the latter is considered to be mitochondrial CK because of its electrophoretic mobility and mitochondrial CK. The relative molecular weight, thermal stability, etc. are not the same as those of the mitochondria CK that have been studied. In order to understand the electrophoretic migration of CK from the CK-MM cathode side, the authors studied the mitochondrial CK in heart and liver tissues.