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目的:探讨ProEx C在宫颈癌及其癌前病变中的表达及意义。方法:应用免疫组织化学SP法检测ProEx C在不同宫颈病变组织芯片中的表达。结果:ProEx C在宫颈炎、CINI、CINII、CINIII及宫颈癌中的阳性表达率分别是25%,51.7%,77.9%,90%,93.8%,且其表达在宫颈癌及CINIII级病变与宫颈炎及CINI级病变相比较差异具有统计学意义(P<0.05),ProEx C在CINI级组织中表达低于CINII级,差异具有统计学意义(P<0.05),ProEx C在浸润性宫颈癌中的表达与临床病理因素无关(P>0.05)。结论:ProEx C反映了细胞的增殖活性,促进宫颈癌的发生发展,可作为诊断及监测预后的指标。
Objective: To investigate the expression and significance of ProEx C in cervical cancer and its precancerous lesions. Methods: Immunohistochemical SP method was used to detect the expression of ProEx C in different cervical lesions. Results: The positive rates of ProEx C in cervicitis, CINI, CINII, CINIII and cervical cancer were 25%, 51.7%, 77.9%, 90% and 93.8%, respectively. (P <0.05). The level of ProEx C was lower than that of CINII in CINI level (P <0.05), and the level of ProEx C in invasive cervical cancer was significantly higher than that of CINI The expression was not associated with clinicopathological factors (P> 0.05). Conclusion: ProEx C reflects the cell proliferative activity and promotes the development of cervical cancer, which can be used as an index to diagnose and monitor the prognosis.