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目的:对脑梗死与同型半胱氨酸(Hcy)以及叶酸水平之间的关系进行分析,观察叶酸干预在对高Hcy血症患者临床的治疗效果。方法:选择52例在我院诊断为脑梗死的患者,设定为观察组,另选择36例非脑梗死患者,设定为对照组,应用酶免疫分析法对患者血浆Hcy的水平进行检测,并应用放免法对叶酸浓度进行测定,在观察组中,对高Hcy血症患者给予5mg的叶酸,每日给药3次,持续给药1周,对患者服药前后的血浆Hcy水平变化情况进行观察。结果:经过治疗,对照组在血浆Hcy浓度方面明显低于观察组,在叶酸浓度方面明显高于观察组,患有高Hcy血症的脑梗死经过1周的叶酸治疗后,血浆Hcy浓度出现下降,平均降低4μmol/L。结论:高梗死患者的血浆Hcy水平出现了显著的上升,应用叶酸干预治疗的方法能够明显降低患者的血浆Hcy浓度。
Objective: To analyze the relationship between cerebral infarction and homocysteine (Hcy) and folic acid levels and to observe the clinical effect of folic acid intervention on patients with high Hcy. Methods: Fifty-two patients diagnosed as cerebral infarction in our hospital were selected as the observation group and another 36 patients with non-cerebral infarction were selected as the control group. Enzyme immunoassay was used to detect the level of Hcy in the patients. And the application of radioimmunoassay to determine the concentration of folic acid in the observation group, patients with hyperhomocysteinemia given 5mg folic acid, daily administration of 3 times, continuous administration for 1 week, before and after treatment in patients with plasma Hcy levels were Observed. Results: After treatment, the plasma concentration of Hcy in the control group was significantly lower than the observation group, the folic acid concentration was significantly higher than the observation group, with high Hcy cerebral infarction after 1 week of folic acid treatment, plasma Hcy concentration decreased , An average decrease of 4μmol / L. Conclusions: The plasma Hcy levels in patients with high infarction have been significantly increased. The application of folic acid intervention can significantly reduce the plasma Hcy levels in patients.