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Discovery of Novel Monocarbonyl Ligustrazine-Curcumin Hybrids as Potential Thioredoxin Reductase Inh
[会议论文] 作者:Zhangjian HUANG,Yong AI,Yihua ZHANG,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
The elevation of oxidative stress preferentially in cancer cells by inhibiting thioredoxin reductase(TrxR)and/or enhancing reactive oxygen species(ROS)has emerged as an effective strategy for selectiv...
[会议论文] 作者:Jianbing Wu,Yihua Zhang,Zhangjian Huang,
来源:2016年长三角药物化学研讨会 年份:2016
Evidence is accumulating that high levels of nitric oxide (NO) could act as a cytotoxic and apoptosis-inducing agent against tumor cells.[1]Diazeniumdiolates derived from secondary amines usually act...
[会议论文] 作者:Jingchao LIU,Wenlong LI,Zhangjian HUANG,Sixun PENG,Yihua ZHANG,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
Rosiglitazone is clinically used to treat insulin resistance.However,its long-term administration will increase the incidence of cardiovascular side effects.[1] Given the beneficial effects of nitric...
Synthesis and Biological Evaluation of GST-π-Based Novel NO-Donating CDDO Derivatives as Potential A
[会议论文] 作者:Fenghua KANG,Yong AI,Zhangjian HUANG,Sixun PENG,Yihua ZHANG,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
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Design,Synthesis and Biological Evaluation of Nitric oxide/Hydrogen Sulfide-Donating Hybrids of 3-n-
[会议论文] 作者:Wei YIN,Jiangen FANG,Zhangjian HUANG,Sixun PENG,Yihua ZHANG,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
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Identification of Nitric Oxide-Releasing Derivatives of Oleanolic Acid as Potential Anti-Colon Cance
[会议论文] 作者:Yu ZOU,Junjie FU,Zhangjian HUANG,Huibin ZHANG,and Yihua ZHANG,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
The overexpressed GSTπ isozyme in tumor cells was regarded as targets for the design of anti-cancer agents.Herein,a group of GSTπ-based nitric oxide(NO)-releasing derivatives of oleanolic acid(OA)(1–9...
Design and synthesis of novel piperlongumine derivatives for intervention of colon cells proliferati
[会议论文] 作者:Yu Zou,Chang Yan,Zhangjian Huang,Huibin Zhang,Yihua Zhang,
来源:2016年长三角药物化学研讨会 年份:2016
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[期刊论文] 作者:Zhuangzhuang Liang,Yunjie Wang,Qinghong Shang,Shengbin Zhang,Cunfang Wang,Mingmin Ni,Dalei Wu,Zhangjian Huang,
来源:药学学报(英文版) 年份:2021
Blood-brain barrier(BBB)damage after ischemia significantly influences stroke outcome.Com-pound LFHP-1c was previously discovered with neuroprotective role in stroke model,but its mechanism of action on protection of BBB disruption after st......
[期刊论文] 作者:Jintong Du,Jing Guo,Dongwei Kang,Zhihong Li,Guan Wang,Jianbing Wu,Zhen Zhang,Hao Fang,Xuben Hou,Zhangjian Huang,
来源:中国化学快报(英文版) 年份:2020
Great success has been witnessed in last decades,some new techniques and strategies have been widely used in drug discovery.In this roadmap,several representati...
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