ChIP-Seq相关论文
花生（Arachis hypogaea L.）是重要的经济油料作物,其生长发育、产量与品质受干旱影响。为深入了解花生的抗旱机理,本研究通过ChIP-se......
目的:乳腺癌是全球女性最常见的恶性肿瘤,严重威胁女性的生命健康。早期筛查和系统治疗显著提高患者的总生存率,但侵袭和转移是导......
DNA元件百科全书（ENCODE,ENCyclopedia Of DNA Elements）计划是后基因组时代基因组序列功能注释的重要国际合作项目。在ENCODE项目的......
猪肉是我国主要的肉类产品,随着国民生活水平的提高,老百姓对猪肉的需求量不断增长,因此提高猪肉产量对国民生活有着重要意义。猪......
油棕（Elaeis guineensis Jacq.）是目前世界上最重要的的油料作物之一,同时也是产油效率最高的油料作物,被誉为“世界油王”。油棕原......
干旱、盐碱和冷害等非生物逆境对作物的产量和品质有重要的影响。淡水资源的缺乏和不利的气候变化是制约水稻生长和稳产的主要因素......
双链RNA结合蛋白ILF3在动物体内广泛存在,被报道参与了包括转录调控、miRNA的生成、RNA稳定性以及响应病毒感染等重要生物学过程。......
转录激活样效应因子（transcription activator-like effector,TALE）作为一种强有力的基因调控和基因组编辑工具,由于繁琐耗时的构建......
柑橘溃疡病是由黄单胞菌柑橘致病变种（Xanthomonas citri subsp.citri,Xcc）引起的检疫性病害,给柑橘产业的健康发展带来极大威胁,培......
RePhine: An Integrative Method for Identification of Drug Response-related Transcriptional Regulator
Transcriptional regulators (TRs) participate in essential processes in cancer pathogenesis and are critical therapeutic ......
Chromatin immunoprecipitation sequencing (ChIP-seq) and the Assay for Transposase-Accessible Chromatin with high-through......
作为生命的主要形态之一,植物进化出一套复杂且高效的基因表达调控机制来调控生长发育和应对外界环境刺激。近年来发表的文献表明,......
梨是主要的多年生温带落叶果树,在我国的种植面积和产量仅次于柑橘和苹果,为第三大果树。长期以来,梨缺少稳定的遗传转化体系,严重......
Genome-wide identification of target genes for transcription factor BR-C in the silkworm,Bombyx mori
Transcription factor Broad Complex (BR-C) is an ecdysone primary response gene in insects and participates in the regula......
目的:筛选出在低氧环境下培养的大鼠CSPCs中,HIF-1α作用的靶基因;探究HIF-1α调控MMP-1在大鼠CSPCs缺氧应答的具体机制;最后,探究......
Histone modifications play critical roles in regulating the expression of developmental genes during embryo development ......
A multicell model for enhancer prediction based on AdaBoost algorithm and shape features of chromati
Background: Accurate identification of DNA regulatory elements has become an urgent need in the post-genomic era.Recentl......
The comprehensive transcriptional analysis in Caenorhabditiselegans by integrating ChIP-seq and gene
Background: The fundamental step of leaming transcriptional regulation mechanism is to identify the target genes regulat......
Anoikis resistance is a hallmark of cancer,and relates to malignant phenotypes,including cell migration,epithelial-mesen......
Genome-wide mapping of the binding sites and structural analysis of KSHV vIRF2 reveal it is a DNA-bi
Oncogenic herpesvirus KSHV is known to encode four viral interferon regulatory factors(vIRF1-4)to subvert host antiviral......
为全面揭示苯并[a]芘(Benzo(a)pyrene,B[a]P)对全基因组DNA序列的损伤,寻找B[a]P致突变和致癌的关键通路和靶点,本研究创新性引入......
传统的免疫共沉淀测序（ChIP-seq）是研究蛋白-染色质相互作用的主流方法，由于ChIP-seq难以在低起始细胞量和单细胞样本上实施限制了其......
Cold acclimation in Arabidopsis thaliana triggers a significant transcriptional reprogramming altering the expression pa......
In eukaryotic chromatin,as epigenetic information is encoded and decoded through the combination function of multipl......
Young课题组(2013年)在人和鼠胚胎干细胞(ESCs)中鉴定了一群具有高度转录活性的增强子功能域,将其命名为超级增强子(Super-enh......
3Disease Browser A Web server for integrating 3D genome and disease-associated chromosome rearrangem
Chromosomal rearrangement (CR) events have been implicated in many tumor and non-tumor human diseases.CR events lead to ......
In eukaryotic chromatin, as epigenetic information is encoded and decoded through the combination function of multip......
Transcription and chromatin regulators, and histone modifications play essential roles in gene expression regulation......
Genetic evidence shows that a quartet of bHLH transcription factors,called PIF1,PIF3,PIF4 and PIF5(for Phytochrome(p......
着丝粒是真核生物染色体上一个特殊的元件,在细胞分裂过程为动粒蛋白复合体提供组装位点,对染色体形态的维持与准确配对分离起至关......
组蛋白修饰指的是在组蛋白在相关酶的作用下发生甲基化、乙酰化、泛素化、磷酸化等翻译后修饰的一种表观遗传调控方式。最近研究发......
猪是我国重要的经济和食物来源,也因其基因组与人类具有高度同源性的特点被用作研究人类疾病的动物模型,因此猪一直是动物遗传领域......
过去几十年里,在生殖生物学领域人们普遍认为与雄性哺乳动物不同,在雌性哺乳动物体内由于缺少生殖干细胞因此在出生之后便失去了在......
胰腺转录因子1a(pancreatic transcription factor 1a,Ptf1a)编码一种碱性螺旋-环-螺旋(basic helix-loop-helix,b HLH)蛋白,在脊......
石杉碱甲(Huperzine A,Hup A)是一种高效中枢乙酰胆碱酯酶抑制剂,可应用于轻中度阿尔茨海默病的治疗。石杉科植物如千层塔是石杉碱......
NAC转录因子为植物所特有,具有丰富的生物功能。课题组发现,前期筛选出的SNAC4-9基因与番茄的生长发育与成熟密切相关。本文通过生......
转录调控是基因表达调控过程中的重要环节,对于转录因子的结合位点的识别是解码转录调控的中心课题之一,并且是理解基因转录调控机......
Asymmetric epigenome maps of subgenomes reveal imbalanced transcription and distinct evolutionary tr
The complexity of the epigenome landscape and transcriptional regulation is significantly increased during plant polyplo......
As a conserved transcription factor,FoxO plays a crucial role in multiple physiological processes in vivo,including stre......
传统的免疫共沉淀测序（ChIP-seq）是研究蛋白-染色质相互作用的主流方法，由于ChIP-seq难以在低起始细胞量和单细胞样本上实施限制了其......
Background:Histone modifications are major factors that define chromatin states and have functions in regulating gene ex......
Cistrome Data Browser and Toolkit: analyzing human and mouse genomic data using compendia of ChIP-se
The Cistrome Data Browser (DB) at the website (cistrome.org/db) provides about 56,000 published human and mouse ChIP-seq......
Background:Gene transcription in eukaryotic cells is collectively controlled by a large panel of chromatin associated pr......
As one of the key technologies in biomedical research,DNA sequencing has not only improved its productivity with an expo......
,New Insights into Aluminum Tolerance in Rice:The ASR5 Protein Binds the STAR1 Promoter and Other Al
...
,H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Mo
Deposition of the histone variant H2A.Z at gene bodies regulates transcription by modifying chromatin accessibility in p......
Transcription factors (TFs) as key regulators play crucial roles in biological processes. The identification of TF–targ......
