Lactam相关论文
Optimal Dose of Meropenem for the Treatment of Neonatal Sepsis:Dosing Guideline Variation and Clinic
Neonatal sepsis is a major disease that threatens the life of newborns,not only has a high incidence rate,but also has a......
A potential dual inhibitor(4) for exogenous absorption and endogenic synthesis of cholesterol was designed based on the ......
ECD spectrometric methods for detecting the enantioselective enzymatic hydrolysis of racemic 3-aceto
(-)-(3R,4S)-3-Acetoxy-4-phenylazetidin-2-one((-)-1) was the key intermediate for preparing optical C-13 side-chain moiet......
An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (L-glutamic acid, D-4-fluoropheny......
Risk factors and antibiotic resistance of pneumonia caused by multidrug resistant Acinetobacter baum
BACKGROUND:With beta-lactam drugs and immunosuppressants widely used,the infection caused by Acinetobacter baumannii(Ab)......
A water-soluble, polythiophene-based colorimetric sensor was designed for selective and sensitive detection of carbenici......
A full account of the novel and flexible approach to hydroxylated 8-azabicyclo[3,2,1]octan-3-ones and 9-azabicyclo[3,3,1......
Design,synthesis and biological evaluation of sulfenimine cephalosporin sulfoxides as β-lactamase in
A series of sulfenimine cephalosporin sulfoxide derivatives(7a–v) were designed, synthesized and evaluated for their in......
当硼替佐米和卡非佐米被FDA批准用于治疗多发性骨髓瘤后,20S蛋白酶体已经作为靶点引起了关注,但这两种药物存在耐药性。作为第二代......
A New Asymmetric Synthesis of (+)-(3R, 4S, 5R, 7S)-Neoclausenamide via Intramolecular Nucleophilic A
An intramolecular nucleophilic substitution of carbon anion to cyclic sulfate was first employed in asymmetric synthesis......
A flexible approach to ethyl (3R, 4S)-N-Boc-4-amino-3-hy-droxy-5-phenylpentanoate (N-Boc-AHPPA-OEt), the γ-ammino-β-h......
Studies on Tripolycyanamide Formaldehyde Resin-Pd Complex and Its Use in the Synthesis of the Branch
A novel method was developed to prepare the branch of paclitaxel using 2,4-dichlorophenylaldehyde as the starting materi......
Syntheses of 4 novel chiral azetidin 2 one derivatives, which were characterized by 1H NMR, IR, specific rotatio......
Two novel poly -oxygen bipyridine alkaloids, speranculatines A (1) and B (2) have been isolated from speranskia tubercul......
本文中 ,SERS被用来测定胆绿素 ,并对溶液中的 p H和 Na Cl浓度对谱图的影响进行了研究。测定下限可达 1 .2 8× 1 0 -7M,且摄谱时......
Spectral and Mechanistic Studies of the Reactions of Substituted 1,5-Benzothiazepine with Dichloroac
A [2+2] cycloaddition adduct 2 and a novel ring-opening product 3 were obtained from the reactions of 2,3-benzothiazepin......
Design,Synthesis and in vitro Evaluation of a New Class of Novel Cyclooxygenase-2 Inhibitors:3,4-dia
design, synthesis and in vivo evaluation of a new class of COX-2 inhibitors 3, 4-diaryl-3-pyrrolin-2-ones are reported.
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IntroductionIn the past several years,much research workhasbeen done forthesynthesisof C- fused bicyclo- β-lactam compo......
The title compound -(N-protected amino)--lactam (C36H33N2O5ClS), derivative of 1,5-benzothiazepine, was prepared by the ......
Mixed solvent of 1-octanol and cyclohexane with 60%(by mass)1-octanol content was selected as a new extractant for capro......
目的 分析某院β-内酰胺类抗生素的使用及病原菌耐药情况,为临床合理用药提供参考依据.方法 统计分析某院2008年1月至2009年12月β......
导言 在美国大约有三分之一的住院患者接受抗生素治疗,大部分用β-内酰胺抗生素(β-lactam antibotics)类:苄青霉素G(Benzyl-penic......
Design and synthesis of novel triazole derivatives containing γ-lactam as potential antifungal agent
A series of novel triazole derivatives containing γ-lactam were designed and synthesized, and their structures were con......
Objective Molecular detection of methicillin resistant S.aureus(MRSA)in the Intensive Care Unit(ICU)will be helpful f......
美《科学》杂志第213卷第1238页(1981年)报道:在最近的美国化学学会的会议上,斯贵宝医学研究所的西马鲁斯蒂(Christopher MCimaru......
The discovery of penicillin in1929,and cephalosporin in 1956 leadto the development of new semisynthetic β-lactam anti......
In 1928 Fleming observed the antibacterial action of penicillin at St.Maryt’s Hospital, London, on a plate seeded with......
临床实践中,β-内酰胺类抗生素常与氨基糖苷类抗生素联用,使用磷酸纤维素作为氨基糖苷类抗生素的灭活剂即可直接用微生物学方法测......
Synthesis of Sodium 2-[4(S)-4-Amido-3-oxo-2-isoxazolidinyl]-5-oxo-2-tetrahydrofurancarboxylate and I
Lactivicin,a novel inhibitor of bacterial cell wall synthesis,was isolated from the culture fil-trates of microorganism......
Introduction:Thoughtheadventofnewer,morepotentandoftenmorewide-spectrumantimicrobialsmayberegardedasworthwhiledevelopmen......
A~1HNMR STUDY ON THE FORMATION AND BREAKING OF INTRAMOLECULAR HYDROGEN BONDS OF BILIRUBIN IN CDCl_3-
The formation and breaking of intramolecular hydrogen bondsof bilirubin in CDCl_3-DMSO-d_6 binary solvent have been inv......
Dipeptide transport: an active process with energy-and proton-dependence in the human intestinal cel
Objective: To determine the active process on dipeptide transport with proton-and energy-dependence in Caco-2 cells.Meth......
1.Patient’s conditions:A lung cancer patient with intravenous infusionneedle retaining in vein more than one week forch......
Four different ZSM 5 zeolites are tested for the gas phase Beckmann rearrangement of cyclohexanone oxime (CHO) into ......
目的:鉴定异长春花苷内酰胺酸催化产物的结构,并探讨其反应机理。方法:用HPLC监控异长春花苷内酰胺酸催化反应过程,采用大孔吸附树......
为研究胆木水提取物中的化学成分,利用D101大孔树脂、硅胶和自动纯化系统等各种色谱手段对其水提取物进行分离和纯化,共得到9个化......
期刊
Objective:To determine the relationship between the application of antibiotic and the production of extended spectrum β......
The concerted reaction mechansim of the ketene-methylenimine cycloaddition reaction was reconfirmed by IRC calculation ......
Many interesting compounds with novel structures and possessing biological activitieshave been isolated from soft coral......
The crystal of the title compound C, C 30 H 30 N 2O 3S has been prepared by reaction of 1,5 benzothiazepine ......
The cleavage and formation of the disulfide bond of 2,5-dimercapto-1,3,4-thiadiazole(DMcT) were examined in an aqueous s......
Characteristics of Baicalin Synergy with Penicillin or Notopterygium Ethanol Extracts Against Staphy
Baicalin facilitates the effectiveness of both penicillin and Notopterygium ethanol extracts (NEE) on Staphylococcus aur......
Aim:To investigate the oxacillin susceptibility restoration of methicillin-resistantStaphylococcus aureus (MRSA) by tar......
A mild two-step method was used to cleave the lactam ring of the tricyclic intermediate 1. A key racemic amino alcohol ......
Prevalence of Panton-Valentine leukocidin genes and antimicrobic resistance in Staphylococcus aureus
Objective To estimate the prevalence of PantonValentine leukocidin(PVL)genes and antimicrobial resistance in methicillin......
Objective: To determine the occurrence of CTX-M producing Escherichia coli(E. coli)from cattle feces in Bogor slaughterh......
New Fragmentation Pathways for Cephalosporins by Electrospray Ionization Quadrupole Time-of-flight M
Introduction Cephalosporinsareantibioticsofβ-lactam family.Theyhaveabroadspectrumofantibiotic activityduetotheirability......
