Retinoids相关论文
Disturbed expression of epidermal lipoxygenases and transglutaminase-1 in ARCI patients: Indications
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Mechanism of retinoid receptors in inhibiting proliferation and inducing apoptosis of human melanoma
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Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, panc
AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic......
目的 探讨全反式维A酸(all-trans retinoic acid,ATRA)、阿维AT和他扎罗汀对人黑素瘤细胞A375凋亡和活性Caspase-3的影响及其意义.......
具有诱导细胞分化作用及癌和皮肤病化学治疗作用的维甲类化合物,不仅要求分子一端有疏水性、另一端为极性羧基和整个分子的共轭性,而......
动物实验提示老龄化影响膳食维生素A在肠道的变化及吸收后的进程。Hollander等在动物灌流实验中发现年龄和维生素A吸收率间几乎呈......
Background: Mateal alcohol exposure and adult alcohol intake have been shown to perturb the metabolism of various micro-......
目的研究补充小剂量全反式维甲酸(ATRA)对酒精喂养大鼠肝脏维生素A类物质(retinoids,主要是维生素A和RA)含量、维生素A类物质极性......
Aim:To investigate the effect of all-trans RA (atRA) on the increases in plas-minogen activator inhibitor-1 (PAI-1) and ......
Retinoids的设计与合成,Strobilurins类似物的设计与合成以及天然产物Strobilurin...
Low-dose ATRA Supplementation Abolishes PRM Formation in Rat Liver and Ameliorates Ethanol-induced L
The effects of all-trans-retinoic acid (ATRA) in low doses supplementation on concentrations of polar retinoid metabolit......
Effect of ATRA on Contents of liver Retinoids, Oxidative Stress and Hepatic Injury in Rat Model of E
The effects of all-trans-retinoic acid (ATRA) administration on the concentration of retinoids (RA and vitamin A) in liv......
Mechanism of retinoid receptors in inhibiting proliferation and inducing apoptosis of human melanoma
Malignant melanoma is a common cancer of skin. Its incidence is growing rapidly in recent years,1 however, there is no ......
Heterocycle-bridged and Conformationally Constrained Retinoids: Synthesis of 4-(7,8,9,10-Tetrahydro-
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
代谢性核受体是一组与糖脂和能量代谢密切相关的核受体,主要包括脂质过氧化物酶体增殖物活化受体、肝X受体、法尼酯衍生物x受体、......
目的:研究维甲酸和干扰素联合应用对膀胱癌细胞的生长抑制和诱导凋亡的作用及其可能分子机制.方法:应用全反式维甲酸(ATRA)和9-顺......
Effect of ATRA on Contents of liver Retinoids, Oxidative Stress and Hepatic Injury in Rat Model of E
The effects of all-trans-retinoic acid (ATRA) administration on the concentration of retinoids (RA and vitamin A) in liv......
To investigate the effects of ATRA, acitretin and tazarotene on the growth and apoptosis of human tongue squamous cell c......
用二正丁基氧化锡和类维生素A酸以摩尔比1:2和1:1反应,合成了两个系列的新型类维生素A酸二正丁基锡酯化合物3a~3d和4a~4d,并利用(^1H,^13C,^......
交链孢醇单甲醚(AME)是直接致突变物,可能是林县食管癌病因之一。维胺酸是国内合成的毒性较小的新维甲衍生物,本文采用V_(79)细胞6......
目的:该研究探讨维甲酸对Bel-7402人肝癌细胞的分化诱导作用,为肝癌的分化治疗提供资料。方法:用维甲酸处理Bel-7402人肝癌细胞,观察细胞增殖、软琼脂集......
采用高效液相色谱法研究56例孔源性视网膜脱离患者的视网膜下液(SRF)及血清维A酸的含量,并观察部分患者服用维生素A对其的影响。结果示,患者SRF中......
RETINOIC ACID NUCLEAR RECEPTORα (RARα),A MAJORROLE IN MEDIATING RETINOIDS INHIBITION OF GROWTH IN HU
RETINOICACIDNUCLEARRECEPTORα(RARα),AMAJORROLEINMEDIATINGRETINOIDSINHIBITIONOF GROWTHINHUMANBREASTCARCINOMACELLSShaoZhimin邵志敏;.........
RETINOIC ACID NUCLEAR RECEPTORα (RARα),A MAJORROLE IN MEDIATING RETINOIDS INHIBITION OF GROWTH IN HU
RETINOICACIDNUCLEARRECEPTORα(RARα),AMAJORROLEINMEDIATINGRETINOIDSINHIBITIONOF GROWTHINHUMANBREASTCARCINOMACELLSShaoZhimin邵志敏;.........
This review provides an overview of relevant aspects of retinoid physiology and molecular biology, and summarizes the cu......
目的设计合成NO供体型维甲酸类化合物,以期获得对乳腺癌肿瘤细胞的增殖有较好抑制作用的化合物。方法将N-(4-羟基苯基)维甲酰胺(4-HPR)......
STUDIESONTHEGAPJUNCTIONALINTERCELLULARCOMMUNICATIONOFHUMANNASOPHARYNGEALCARCINOMA CELLSANDTHEEFFECTOFRIIHanLiqun韩立群;GaoJin高进;.........
使用比较分子场分析法建立了一个维甲类化合物抗致癌活性的三维构效关系模型,用交叉验证法、和非交叉验证方法分别验证和建立的分子......
准确地预测配体-受体的结合常数是基于受体结构设计的一个重要方面。目前几乎所有的全新设计数据库搜寻的方法都则重于结构的生成而......
Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, panc
AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic......
胰岛素样生长因子结合蛋白7( IGFBP7)属于胰岛素样生长因子结合蛋白超家族成员,参与细胞内信号转导、细胞生长及细胞代谢,在人类多种组......
为了研究水环境中维A酸受体活性的成因,于2009年3~7月对清河河道进行了4次采样分析,利用固相萃取柱富集与重组基因酵母结合测试方法......
大疱性鱼鳞病是一种少见的常染色体显性遗传性皮肤病,临床以皮肤过度角化为主要表现,并有3种临床亚型.其发病主要由K1、K10和K2e角......
维A酸类化合物对恶性肿瘤的预防和治疗作用越来越受到人们的关注,它对肿瘤细胞具有促进凋亡、抑制生长、诱导分化等作用,这均与细胞......
目的 探讨丹参酮联合0.025%维A酸霜治疗痤疮的疗效。方法 选择2005年3月-2006年7月门诊痤疮患者90例,随机分为口服丹参酮组(A组)、维A酸......
代谢性核受体是一大类配体激活核受体转录因子,作为糖尿病治疗的新靶点日益受到国内外学者的关注。维甲酸隶属于代谢性核受体,是维......
利用高效反相液相色谱法检测了夏冬两季受有机氯污染的典型湖泊——鸭儿湖严家湖区鲢肝中的视黄醇,软脂酸视黄酯及α-生育酚的含量......
To investigate the effects of ATRA, acitretin and tazarotene on the growth and apoptosis of human tongue squamous cell c......
Low-dose ATRA Supplementation Abolishes PRM Formation in Rat Liver and Ameliorates Ethanol-induced L
<正>The effects of all-trans-retinoic acid (ATRA) in low doses supplementation on concentrations of polar retinoid metab......
Effect of ATRA on Contents of liver Retinoids, Oxidative Stress and Hepatic Injury in Rat Model of E
The effects of all-trans-retinoic acid(ATRA) administration on the concentration of retinoids(RA and vitamin A) in liver......
目的:探讨合成的第三代维甲类化合物(E)-4「2-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl-1-propenyl」benzoic acid(Rol3-7410)对白血病细胞HL-60的影响。方法:采用NBT还原能力测定检测细胞分化,电和程序性细胞死亡检测试剂盒鉴......
目的:观察神经母细胞瘤细胞在被维甲类化合物诱导分化过程中细胞形态、细胞周期及端粒酶基因表达方面的变化,探讨其作用机理及临床意......
RETINOIC ACID NUCLEAR RECEPTOR α(RARα) PLAYS A MAJOR ROLE IN RETINOID-MEDIATED INHIBITIONOF GROWTH I
Retinoids mediate their actions via retinoic acid receptors (RARα) and retinoid X receptors (RXRs). Each of class of th......
Most therapeutic protocols for child cancers use cytotoxic agents which have a narrow therapeutic index,and resulting in......
目的探讨全反式维A酸(ATRA)、阿维A及他扎罗汀对人黑色素瘤细胞A375凋亡及Bax/Bcl-2蛋白表达的影响及其意义.方法采用体外培养和流......
目的研究维A酸抑制人类舌鳞癌Tca8113细胞株的增殖和诱导凋亡的受体机制.方法用MTT法和细胞周期分析法研究3种维A酸(9-cis-RA、at-......
RetinoJds(RNDs)指天然或合成的各种维生素A(VA)的代谢物或类似物.包括维甲醇.维甲醛.维甲酸(rednoic acid.RA)及维胺酸维胺脂等.RA衍生......
目的:研究补充小剂量全反式维甲酸(ATRA)对酒精喂养大鼠肝脏维生素A类物质(reti.noids,主要是维生素A和RA)含量、维生素A类物质极性代谢产......