β-amyloid相关论文
Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-am
Background::Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease (AD). Ho......
Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-am
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Physalin B(PB),one of the major active steroidal constituents of Solanaceae Physalis plants,has a wide variety of bio-lo......
Huannao Yicong Formula(还脑益聪方) Regulates γ-Secretase Activity through APH-1 and PEN-2 Gene Ragulation
Objective:To observe the effects of Huannao Yicong Formula(还脑益聪方, HYF) on learning and memory and it\'s regulatin......
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Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in
Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer\'s disease (AD),and insulinresistance is commo......
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ productio
Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease.Generation of Aβ involves......
Aim: Recently, research of the contribution of activated microglia in Alzheimers disease (AD) has become a new research ......
The selective BACE1 inhibitor Vla reduces Aβ production and ameliorates behavioral deficits in a mou
Aim: We are pursuing potent BACE1 inhibitors in an effort to identify suitable AD drug candidates.Methods: Employing a h......
Protection of β-Amyloid-induced Oxidative Cell Death and Enhancement of Cognitive Dysfunction by [6]
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Mitochondrial ferritin attenuates β-amyloid-induced neurotoxicity: Reduction in oxidative damage thr
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Blocking mPTP on neural stem cells and activating the nicotinic acetylcholine receptor α7 subunit on
Background: β-Amyloid(Aβ)can stimulate microglia to release a variety of proinflammatory cytokines and induce neurotox......
Inhibition of LTP by β-amyloid is prevented by activation of β2 adrenoceotors and stimulation of cAM
The present study investigated the role of β-adrenoceptors and the downstream cAMP/PKA signaling pathway on the A β in......
Cerebral ischemia-induced astrocyte apoptosis associated with increases of beta-secretase expression
The aberrant proteolytic processing of amyloid precursor protein (APP) by b-secretase (BACE 1) and g-secretase is import......
OBJECTIVE Abnormally increased production and accumulation of β-amyloid(Aβ)is the most prominent hallmark of Alzheimer......
Background: Alzheimers disease (AD),the most common cause of dementia,is a progressive and fatal neurodegenerative disor......
The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflamm
Objective β-Amyloid (Aβ) peptides play an important role in cognition deficits, neuroinflammation, and apoptosis obser......
Effects of mild induced hypothermia treatment on rat hippocampal β-amyloid expression following trau
Background: Mild induced hypothermia (MIH) treatment has positive effects on traumatic brain injury (TBI) outcomes, whic......
Mitochondrial respiratory inhibition and oxidative stress elevate β-secretase (BACE1) proteins and a
Purpose Cerebral hypo-metabolism,oxidative stress and β-amyloid peptide (Aβ) accumulation are key pathological events ......
PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of ty
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PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of ty
OBJECTIVE Pioglitazone, known as a peroxisome proliferator-activated receptor γ (PPARγ) agonist, is used to treat type......
Alzheimer’s disease(AD)is a progressive and fatal neurodegenerative condition and the most prevalent cause of dementia.......
The protective effect of Recombinant Buckwheat Trypsin Inhibitor in a Caenorhabditis elegans Model o
Alzheimers disease (AD) is a rising threat for modern societies as more and more people reach old age.To date,there ......
目的 观察淫羊藿黄酮对β-淀粉样肽(Aβ)拟阿尔茨海默病(AD)模型小鼠学习记忆能力的影响.方法 将ICR小鼠随机分为正常组、假手术组......
目的研究黄酮类化合物漆黄素对Aβ诱发小鼠学习功能障碍的影响。方法通过侧脑室植入的引导管灌注Aβ (1-42) 建立AD小鼠模型。Aβ......
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rat
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Comparative study of histopathology changes between the PS1/APP double transgenic mouse model and Aβ
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阿尔茨海默病（ AD）是一种慢性神经退行性疾病，β淀粉样蛋白（ Aβ）在海马过度沉积形成的老年斑是其主要的病理特点。 Aβ激活胶质细胞介......
Study on the Protective Effects and Mechanisms of Dendrobium Nobile Lindle.Alkaloids on PC12 Cells i
Objective:This study was designed to investigate the protective effect of Dendrobium nobile Lindle. Alkaloids(DNLA)on th......
目的观察原花青素对β淀粉样蛋白25-35(Aβ25-35)诱导的小鼠学习记忆损伤的早期影响及其影响途径。方法30只成年C57bl/6小鼠，随机分......
目的 研究β-淀粉样蛋白(Aβ25-35)对大鼠海马细胞内质网钙库的影响.方法 将40只成年清洁级雄性SD大鼠按体重随机分为4组,分别为A......
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative condition and the most prevalent cause of dementi......
目的 探讨不同剂量氯化甲基汞蓄积时长差异对成年大鼠记忆力及脑组织中Aβ1-42的影响.方法 通过灌胃给予大鼠不同剂量的氯化甲基汞......
阿尔茨海默症(Alzheimer’s disease,AD)是老年人群中最常见的认知障碍疾病之一.阿尔茨海默症与糖尿病(diabetes mellitus,DM)拥有......
线粒体是一种重要的细胞器,时刻处在分裂和融合的动态循环中,通过动力学过程发挥其功能。打破线粒体动力学平衡会导致线粒体功能出......
,Protective effects of compound FLZ, a novel synthetic analogue of squamosamide, on β-amyloid-induce
Aim: The aim of the present study was to assess the effects of N-[2-(4-hydroxyphenyl)ethyl]-2-(2,5-dimethoxyphenyl)-3-(3......
Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibiti
Amyloid precursor protein (APP) and iron both play pivotal roles in the central nervous system,but whether and how iron ......
Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer’s
Drug repurposing is an efficient strategy for new drug discovery.Our latest study found that nitazoxanide (NTZ),an appro......
Structural Features of Human Memapsin 2 (β-Secretase) and Their Biological and Pathological Implicat
Memapsin 2 (β-secretase) is the membrane-anchored aspartic protease that initiates the cleavage of β-amyloid precursor......
Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer
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过量的铜离子介导淀粉样蛋白异常聚集被认为是导致淀粉样蛋白变性病的主要因素之一.基于淀粉样蛋白聚集机理及金属铜离子的氧化还......
目的探讨骨桥蛋白(OPN)和白细胞介素17(IL-17)在β淀粉样蛋白(Aβ)神经毒性及阿尔茨海默病(AD)病理机制中的作用。方法36只成年雄......
目的研究β-淀粉样蛋白(Aβ)对原代培养的大鼠脑海马神经细胞内钙稳态相关蛋白Sorcin 、RyR2mRNA的影响。方法新生1-3天的Wistar大......
Alzheimer’s disease is a common progressive neurodegenerative disorder, pathologically characterized by the presence of......
