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Objectives: To study the effect of ligustrazine to the gene of fibrinogen with genechip and RT PCR through the rat model of renal ischemia and reperfusion.Methods: SD rat to random divide into two groups: The experimental group with ligustrazine treatment and the control group without ligustrazine treatment.The experimental rat group are treated with ligustrazine for 1 week, before remove the right renal ,after ischemia.The occlusion of the right renal artery 60 minute to make the induce renal failure, and then check the right ranal genchip and RT PCR.Results: 1.The content of the fibrinogen concentration is 3.48±0.64g/L in the control group and the Ligustrazine group is 3.90±0.68g/L of the renal ischemia, that in the control whereas the concentration is 6.40±0.87g/L in control group and the Ligustrazine is 5.28±0.76g/ L in Ligustrazine treatment group of the renal after renal reperfusion of the renal.2.The genechip result of gene of fibrinogen is cy5: 377,cy3: 3049, Ratio gene is 0.113 indicating down regulation of the gene.3.The PCR amplification spectrum of the experimental group is dimmer than that of the blank group.Conclusion: Ligustrazine could protect the kidney under ischemic and reperfusion condition by down-regulation to fibrinogen gene and then to lighten to poison it .