Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeabilit

来源 :第八届广州国际干细胞与再生医学论坛暨第四届中国再生细胞生物学年会 | 被引量 : 0次 | 上传用户:itcrasher9999
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Valproic acid(VPA)is widely used to treat epilepsy,migraine,chronic headache,bipolar disorder,and as adjuvant chemotherapy,but potentially causes idiosyncratic liver injury.
其他文献
Background and purpose: Retinal degenerative diseases are the major causes of vision loss without effective treatment so far.Human induced pluripotent stem cells(hiPSC)hold great promise for treating
会议
会议
An atlas of human methylation marks reveals cell-type-specific hypomethylation at super-enhancers.DNA methylation is a key epigenetic mark that is critical for gene regulation in multicellular eukaryo
会议
As the most aggressive primary brain tumor,glioblastoma multiforme(GBM)poses great threats to the health of human being.Yet clinical treatment for this lethal disease remains quite limited.
会议
Super-enhancers are large clusters of transcriptional enhancers regarded as having essential roles in driving the expression of genes that control cell identity during development and tumorigenesis.
会议
Aim: To investigate the potential role of bone marrow stromal cells(BMSCs)in protecting neurons under the inflammatory condition induced by microglial cells(MG)and to reveal its possible mechanism.
会议
Nr5a2(nuclear receptor subfamily 5,group A,member 2/liver receptor homologue-1,Lrh-1)exhibits broad expression during the morula and epiblast stages of development.
会议
Utilization of small molecules in modulation of stem cell self-renewal or fate decision is one of the promising approaches to expand pluripotent stem cells for regenerative therapy.
会议