【摘 要】
：
AIMS: This study aimed to investigate the contribution of genetic polymorphisms of SLCO1B1 arid ABCG2 to the pharmaeokinetics of a dual substrate, rosuvastatin.METHODS: Among 120 subjects genotyped fo
【机 构】
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Pharmacy department, Shengjing Hospital, China Medical University, Shenyang 110013, China
【出 处】
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中国药理学会生化与分子药理专业委员会2014年研讨会
论文部分内容阅读
AIMS: This study aimed to investigate the contribution of genetic polymorphisms of SLCO1B1 arid ABCG2 to the pharmaeokinetics of a dual substrate, rosuvastatin.METHODS: Among 120 subjects genotyped for OATP1B1 c.388A＞G, c.521T＞C and BCRP c.421C＞A, 30 subjects were selected for the rosuvastatin pharmacokinetic study.Twenty milligram dose of rosuvastatin was administered orally to-the volurteers.The plasma concentration of rosuvastatin was measured for up to 96 h by liquid chromatography-mass spectrometry (LC/MS/MS).
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