【摘 要】
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Activity-induced long-term synaptic modification depends on the frequency of synaptic activation,a property extensively studied at glutamatergic synapses.At developing GABAergic synapses on CA1 hippoc
【机 构】
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Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sci
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Activity-induced long-term synaptic modification depends on the frequency of synaptic activation,a property extensively studied at glutamatergic synapses.At developing GABAergic synapses on CA1 hippocampal neurons,we found that coincident pre-and postsynaptic spiking also led to a persistent modification of the amplitude of depolarizing GABAergic postsynaptic potentials (GPSPs) in a frequency-dependent manner:Spiking at 20-50 Hz resulted in synaptic potentiation,whereas spiking at 5 Hz led to synaptic depression.This bi-directional modification of GABAergic synapses was accompanied by bi-directional shift in the reversal potential of GABA response.
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