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Objective: To analyze the changes in tumor volume during intensity-modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC).Methods: Twenty-five NSCLC patients were treated with IMRT.All patients underwent simulation CT scans before IMRT at doses of 20, 30, 40, 50.5, and 61 Gy.Target volumes were delineated on every CT scan.The changes in gross tumor volume(GTV) and gross target volume of mediastinal nodes (GTYnd)were analyzed.