【摘 要】
：
The project is part of a broader program of developing new oxazaphosphorines.Cyclophosphamide (CPM) and ifosfamide (IFM).These two major anticancer drugs have been chosen to demonstrate the concept of
【机 构】
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the Pharmacology and Drag Analysis Department Institut Gustave Roussy France
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The project is part of a broader program of developing new oxazaphosphorines.Cyclophosphamide (CPM) and ifosfamide (IFM).These two major anticancer drugs have been chosen to demonstrate the concept of targeting pre-activated prodrugs which are phosphoramide mustards.CPM and IFM are prodrugs whose cytotoxic activity is associated with metabolic activation cytochrome P450-dependent especially in high dose regimens.The main interest lies in stabilizing the oxidized form of IFM on position 4 to propose complementary routes of administration of the drug.
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