【摘 要】
：
The design,synthesis,and biological activity evaluation of the potency of new inhibitors of sphingosine kinases 1 and 2(SphK1 and SphK2),the enzyme that catalyzes the phosphorylation of D-erythro-sphi
【机 构】
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State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia
【出 处】
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2015年全国药物化学学术会议暨第五届中英药物化学学术会议
论文部分内容阅读
The design,synthesis,and biological activity evaluation of the potency of new inhibitors of sphingosine kinases 1 and 2(SphK1 and SphK2),the enzyme that catalyzes the phosphorylation of D-erythro-sphingosine to produce the key signaling lipid,sphingosine 1-phosphate1,are described.Recently,we reported that(E)-N-(4-(benzyloxy)benzylidene)-3,4,5-trihydroxybenzohydrazide(compound 25)was a novel inhibitor of SphK1 and SphK22.
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