【摘 要】
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Objective Recent findings have implicated that HapB haplotype was significantly associated with stroke.The aim of this study was to explore the association between haplotypes of ALOX5AP gene and risk
【机 构】
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Department of Medical Genetics, Basic Medical College of ZhengZhou University
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Objective Recent findings have implicated that HapB haplotype was significantly associated with stroke.The aim of this study was to explore the association between haplotypes of ALOX5AP gene and risk of ischemic stroke (IS) in Chinese Han population.Methods A total of 246 patients with ischemic stroke and 245 matched control subjects were recruited.Four ALOX5AP SNPs (SG13S377, SG13S114, SG13S41,and SG13S35) were genotyped by SNaPshot minisequence technique.Odds ratios and 95% confidence intervals (95% CI) were caleulated to test the association between the variants and IS.Results A common genetic variant SG13S114/AA in the ALOX5AP gene was associated with an increased risk for ischemic stroke in Chinese males (OR=2.667, 95%CI=1.245~5.711).HapB (AAAG) had no significant difference in the patients (18.5%) and controls(16.3%) (P =0.374).The frequency of Hap (AAGG) was significantly higher in the patients than in controls (OR =1.599, 95%CI=1.142~2.239).While Hap(ATGG) of ALOX5AP was significantly lower in the patients than in controls (OR =0.745, 95%CI=0.576 ~ 0.965).Conclusions Two novel Hap(AAGG) and Hap(ATGG) of ALOX5AP gene are testified to be associated with IS in Chinese Han Population.
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