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Isochrysis zhanjiangensis is a marine unicellular microalgae.It has been reported that Isochrysis galbana have considerable total lipid content 20-40% (w/w) (Fidalgo et al., 1998) and is rich in polyunsaturated fatty acids (Jeffrey et al., 1994).However, the information about I.zhanjiangensis is rare.Effect of nitrate feeding on the cell growth and lipid accumulation of marine microalgae Isochrysis zhangjiangensis was investigated.