As one promising optimization methodology, constructal approach is employed to designthe multi-scale apparatuses, such as fluid distributors and mixers in this thesis, which aretaken as constnzctal prototype for actual engineering application. For the purpose of uniformly distributing the fluid into micro-scale structured channelswhere the heat/mass transfer can be obviously intensified, with minimum energy dissipationand residence time/hold-up volume, a 2-dimensional tree-like distributor with 16 outlets isconstructed by combining three components, including fluid inlet plate, distributing plate withbifurcation channels, and outlet plate, the geometry dimensions of the connecting channels onthe distributing plate are calculated according to the constructal approach. Throughexperimental investigation, the results indicate that this 2-D distributor can achieve uniformflow distribution and has good redistribution performance. In order to fmd the guidelines to optimize the distributor design procedure, theComputational Fluid Dynamics (CFD) simulation is applied to investigate the effects of thedistributors configuration on the flow distribution performance and pressure drop. Thesymmetrical principle of furcation is proved important to guarantee the uniform flowdistribution, and the connecting channels that have the nature-imitating structure andgradually reducing size arerecommended because of the greatly diminished engrey dissipation. Process intensification of mini heat exchange system is achieved by the introduction ofconstructal distributors, which act as an effcient connection between the micro-scale wherethe heat transfer intensification is dominating and the macro-scale where the actualengineering operation is available. The thermal performance, in terms of overall heat transfercoefficient, of the heat exchange system, which is the integration of mini cross-flow heatexchanger and constructal distributor with 128 outlets, is intensified to an increase of 30%compared with that when the conventional pyramid distributors are used, owing to theuniform flow distribution achieved by the employment of constructal components. A constructal mixer is designed and fabricated, which is the integrated devices of the elemental impinging streams mixing units or jet mixing units, and its mixing performance isinvestigated with heterogeneous and homogeneous liquid-liquid mixing. The effects of the configuration of the collector, geometrical dimension of the injectors. the way the inlet fluidsflow into, are evaluated experimentally. The results imply that the constructal mixer can notonly mix immiscible liquids well, but also mix the miscible liquids very quickly. Theexcellent mixing performance and high throughput make the mixer promising for actualindustrial application.