论文部分内容阅读
目的 :探讨孕期妇女甲状腺过氧化物酶抗体(TPOAb)与甲状腺球蛋白抗体(TgAb)阳性对新生儿甲状腺功能的影响。方法 :264例妊娠期妇女根据TPOAb、TgAb检测结果分为TPOAb阳性组与阴性组、TgAb阳性组与阴性组,分别对比TPOAb阳性组与阴性组、TgAb阳性组与阴性组新生儿足跟血促甲状腺激素(TSH)水平、亚临床甲减发生率,并分析孕妇TPOAb、TgAb与新生儿TSH相关性。结果 :TPOAb阳性组与TgAb阳性组新生儿TSH水平、亚临床甲减发生率均显著高于TPOAb阴性组与TgAb阴性组;孕妇TPOAb及TgAb水平均与新生儿TSH水平呈显著正相关。结论 :孕期TPOAb与TgAb阳性孕妇的新生儿TSH水平及亚临床甲减发生率明显增高,应加强孕期TPOAb与TgAb阳性孕妇所产新生儿的早期甲状腺功能筛查,并及干预,降低临床甲减发生率,促使患儿健康发育成长。
Objective: To investigate the influence of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) positivity on thyroid function in newborn during pregnancy. Methods: According to the results of TPOAb and TgAb, 264 pregnant women were divided into two groups: TPOAb positive group and negative group, TgAb positive group and negative group respectively, which were respectively compared with TPOAb positive group and negative group, TgAb positive group and negative group Thyroid hormone (TSH) levels, the incidence of subclinical hypothyroidism, and analysis of pregnant women TPOAb, TgAb and neonatal TSH correlation. Results: The levels of TSH and subclinical hypothyroidism in TPOAb positive group and TgAb positive group were significantly higher than those in TPOAb negative group and TgAb negative group. The levels of TPOAb and TgAb in pregnant women were positively correlated with the TSH level in newborns. Conclusion: TSH levels and the incidence of subclinical hypothyroidism in newborns with TPOAb and TgAb positive pregnancy during pregnancy are significantly higher. Early thyroid function screening should be strengthened in neonates with TPOAb and TgAb positive pregnancy during pregnancy, and intervention should be made to reduce clinical hypothyroidism The incidence of children with healthy development and growth.