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目的考察淫羊藿(Herba Ep im ed ii,HE)和三七(Rad ix Notoginseng,RN)乙醇提取物组合对大鼠的活血化瘀作用及对东莨菪碱造模智障小鼠被动回避的影响,为该组合物治疗老年性痴呆提供实验依据。方法大鼠连续ig HE和RN提取物组合(1,3.1g/kg)7d,采用试剂盒测定该组合物对大鼠血清凝血酶原时间(PT)、部分凝血活酶时间(KPTT)的影响,用下腔静脉结扎法考察其对大鼠下腔静脉血栓形成的影响。此外,采用相同剂量及给药方法考察了HE和RN提取物组合对东莨菪碱造模智障小鼠被动回避的影响。结果连续ig HE和RN提取物组合(1,3.1g/kg)可显著延长KPTT(P<0.05),而对PT没显著性影响(P>0.05);能显著预防下腔静脉血栓的形成(P<0.01);在活血化瘀作用剂量下HE和RN提取物组合对东莨菪碱造模小鼠被动回避没显著性影响(P>0.05)。结论HE和RN提取物组合具有显著的活血化瘀作用,但对东莨菪碱造模智障小鼠被动回避无显著影响。
Objective To investigate the effects of Herba Epimedii (HE) and Radix Notoginseng (RN) ethanol extracts on blood circulation and phlegm-removal in rats and passive avoidance of scopolamine-induced mental retardation mice. The composition provides experimental basis for treating senile dementia. Methods The rats were continuously ig HE and RN extract combination (1, 3.1 g/kg) for 7 days. The effect of the composition on serum prothrombin time (PT) and partial thromboplastin time (KPTT) in rats was determined using a kit. The effect of inferior vena cava thrombosis on rat thrombosis was investigated by inferior vena cava ligation. In addition, the effects of the combination of HE and RN extracts on the passive avoidance of scopolamine-induced mental retardation mice were investigated using the same dose and administration method. Results Continuous ig HE and RN extract combination (1, 3.1 g/kg) significantly prolonged KPTT (P<0.05), but had no significant effect on PT (P>0.05); it could significantly prevent the formation of inferior vena cava thrombosis ( P<0.01); The combination of HE and RN extracts had no significant effect on the passive avoidance of mice modeled by scopolamine (P>0.05). Conclusion The combination of HE and RN extracts has a significant effect on promoting blood circulation and removing blood stasis, but it has no significant effect on the passive avoidance of scopolamine-induced mental retardation mice.