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目的观察低剂量5-氟尿嘧啶(5-FU)持续静脉滴注治疗常规含5-FU类方案失败的进展期结直肠癌的近期疗效和毒副反应。方法 17例经传统的一、二线方案化疗失败的进展期结直肠癌患者,给予5-FU 200 mg/m2/d微量泵持续静脉滴注,治疗至疾病进展。结果全组17例均可评价,其中完全缓解(CR)0例,部分缓解(PR)2例,稳定(SD)7例,进展(PD)8例,有效率(RR)11.7%,临床获益率(CR+PR+SD)52.8%。毒副反应主要是I～Ⅱ级口腔黏膜炎和手足综合征。结论低剂量5-氟尿嘧啶持续静脉滴注治疗常规含5-FU方案失败的进展期结直肠癌的近期疗效较好,毒副反应较低,值得进一步研究应用。
Objective To observe the short-term efficacy and side effects of continuous low-dose 5-fluorouracil (5-FU) infusion in patients with advanced colorectal cancer who have failed conventional 5-FU regimen. Methods Seventeen patients with advanced colorectal cancer who had failed the traditional first-and second-line chemotherapy regimens were given intravenous infusion of 5-FU 200 mg / m 2 / d micro-pump continuously until the disease progressed. Results All the 17 patients could be evaluated. There were 0 complete remission (CR), 2 partial remission (PR), 7 stable (SD) and 8 progressive (PD) patients. The effective rate was 11.7% Rate of return (CR + PR + SD) 52.8%. Toxic side effects are mainly grade I ~ II oral mucositis and hand-foot syndrome. Conclusion Continuous infusion of low-dose 5-Fluorouracil for the treatment of advanced colorectal cancer with conventional 5-fluorouracil-containing regimen has better curative effect and lower toxic and side effects, which deserves further study.