Hatzimouratidis K等人进行了一项研究对ED治疗方法进行对比回顾。近20年,在勃起功能障碍领域发生了巨大的变革。现在有多种治疗方法可以选择,大多数方法都有很高的有效率和良好的安全性。为评价目前治疗ED的不同方法所获得的数据,已经开展了一项MEDLINE研究。磷酸二酯酶-5(PDE_5)抑制剂(如西地那非、他达拉非、伐地那非)都是临床医师和ED患者的一线选择用药。PDE_5抑制剂在药物代谢动力学方面表现迥异,最突出的就是他达拉非有较长的药物持续时间,而在药物效果和安全性方面没有数据证明 Hatzimouratidis K et al conducted a study comparing the ED treatment. In the past 20 years, great changes have taken place in the field of erectile dysfunction. There are a variety of treatment options available, most of which are highly effective and safe. To evaluate the data obtained by the different methods currently used to treat ED, a MEDLINE study has been conducted. Phosphodiesterase-5 (PDE 5) inhibitors (such as sildenafil, tadalafil, vardenafil) are first-line options for clinicians and ED patients. PDE-5 inhibitors perform very differently in pharmacokinetics, most notably the long duration of tadalafil but no data on the efficacy and safety of the drug