【摘 要】
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Several subsets of T-regulatory (Tr) cells with distinct phenotypes and distinct mechanisms of action have been identified. These include Tr type 1 (Tr1) cells;
【机 构】
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Department of Transplantation
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Several subsets of T-regulatory (Tr) cells with distinct phenotypes and distinct mechanisms of action have been identified. These include Tr type 1 (Tr1) cells; Th3 cells, which primarily secrete transforming growth factor (TGF)-β; and CD4+CD25+ T cells, which inhibit immune responses through cell to cell contact.1 It has been shown that CD4+CD25+ immunoregulatory T cells induced by the blockade of CD154-CD40 pathway are tolerant to alloantigen, resulting in secondary mixed lymphocyte reaction (MLR) hyporesponsiveness in vitro and tolerance to alloantigen in vivo.2,3 Previous studies mainly paid attention to CD4+CD25+ immunoregulatory T cells induced by CD154-CD40 blockade, but it was unclear whether CD154-CD40 blockade might induce Tr1 or Tr1-like cells.
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