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目的探讨佐米曲普坦鼻喷雾剂治疗偏头痛急性发作的效果。方法选择2010年1月—2012年1月收治的偏头痛急性发作患者102例,随机分为观察组和对照组各51例。观察组给予佐米曲普坦鼻喷雾剂喷鼻1喷/次(即2.5mg),对照组予舒马普坦胶囊2粒/次。比较用药15、30、45min及2h后疼痛改善情况。计数资料采用χ2检验,P<0.05为差异有统计学意义。结果用药15、30、45min总有效率观察组分别为31.37%、54.90%、78.43%,对照组分别为13.73%、35.29%、58.82%,两组比较差异均有统计学意义(均P<0.05),用药2h总有效率观察组94.12%,对照组82.35%,两组比较差异无统计学意义(P>0.05)。两组患者均未发生严重不良反应。结论佐米曲普坦鼻喷雾剂可迅速缓解偏头痛急性发作,且迅速起效作用优于舒马普坦胶囊,具有良好的耐受性,值得临床推广使用。
Objective To investigate the effect of Zopicltone nasal spray on acute migraine attacks. Methods A total of 102 acute migraine patients admitted from January 2010 to January 2012 were randomly divided into observation group (51 cases) and control group (51 cases). The observation group was treated with Zopicliptan nasal spray 1 spray / time (2.5mg), while the control group was given Shumaputan capsule 2 capsules / time. The pain was improved after 15, 30, 45 and 2 hours of treatment. Count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate of observation group were 31.37%, 54.90% and 78.43% at 15, 30 and 45 minutes respectively. The control group was 13.73%, 35.29% and 58.82% respectively, with significant difference between the two groups ). The total effective rate of 2 hours in the observation group was 94.12% in the observation group and 82.35% in the control group. There was no significant difference between the two groups (P> 0.05). No serious adverse reactions occurred in both groups. Conclusion Zomitriptan nasal spray can quickly relieve acute migraine attacks, and rapid onset of action is superior to sumatriptan capsules, with good tolerance, it is worth promoting the use of the clinic.