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目的 :观察补中益气汤含药血清等 8种制剂体外给药对大鼠胃壁细胞胃泌素受体结合作用的影响。方法 :放射配基受体结合法。结果 :补中益气汤含药血清、参麦注射液、黄芪多糖能抑制大鼠胃壁细胞胃泌素受体与12 5I 胃泌素的特异性结合。结论 :补中益气汤含药血清等对大鼠胃壁细胞胃泌素受体的结合作用有一定影响 ,补中益气汤调节胃泌素受体复健脾虚证的机理可能在于与胃泌素受体竞争性结合。
Objective : To observe the effect of in vitro administration of Buzhong Yiqi Decoction serum and other drugs on gastrin receptor binding in rat parietal cells. Methods: Radioligand receptor binding method. RESULTS: Buzhong Yiqi Decoction serum, Shenmai Injection and Astragalus Polysaccharide could inhibit the specific binding of gastrin receptor and 12 5 I gastrin in gastric parietal cells of rats. Conclusion: The serum containing Buzhong Yiqi Decoction has certain influence on the binding of gastrin receptors in gastric parietal cells in rats. The mechanism of Buzhong Yiqi Decoction regulating gastrin receptors in restoring spleen deficiency syndrome may be related to gastrin secretion. Receptor competitive binding.