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目的探讨维生素C、B6及纳络酮联合治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法采用随机对照,治疗组在综合治疗的基础上加用维生素C、B6及纳络酮;对照组只进行综合治疗,进行疗效比较。结果治疗组在T、R、P改善上及临床症状评分都明显好于对照组,治疗组病死率30%(3/10),对照组病死率60%(6/10)。差异有显著性。结论大剂量维生素C、B6及纳络酮联合治疗新生儿缺氧缺血性脑病近期疗效明显。
Objective To investigate the curative effect of vitamin C, B6 and naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods A randomized controlled trial was conducted. The treatment group was given vitamin C, B6 and naloxone on the basis of comprehensive treatment. The control group was only treated with comprehensive treatment, and the curative effect was compared. Results The improvement of T, R and P and the score of clinical symptoms in the treatment group were significantly better than those in the control group. The treatment group was 30% (3/10) and the control group was 60% (6/10). The difference was significant. Conclusion High dose of vitamin C, B6 and naloxone combined treatment of neonatal hypoxic-ischemic encephalopathy has obvious short-term curative effect.