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目的比较同期推量放射治疗(SIB)和全脑照射+三维适形放射治疗(WBRT+3DCRT)序贯治疗在肺癌脑转移患者中的应用效果。方法收集2006年1月至2011年4月间152例患者行SIB(研究组),146例肺癌脑转移瘤患者行WBRT+3D-CRT序贯治疗(对照组),比较两组患者的临床效果。结果研究组患者的客观缓解率、疾病控制率和1年生存率均高于对照组,差异均有统计学意义(均P<0.05)。研究组患者中位无进展生存时间明显延长,与对照组差异有统计学意义(P<0.05)。结论 SIB能提高肺癌脑转移瘤患者的客观缓解率、疾病控制率和1年生存率,同时能延长中位生存时间。
Objective To compare the effects of sequential radiotherapy (SIB) and whole brain irradiation + three dimensional conformal radiotherapy (WBRT + 3DCRT) on patients with brain metastases from lung cancer. Methods 152 patients with SIB (study group) and 146 patients with brain metastases of lung cancer underwent WBRT + 3D-CRT sequential therapy (control group) from January 2006 to April 2011. The clinical effects of two groups were compared . Results The objective response rate, disease control rate and 1-year survival rate of the study group were significantly higher than those of the control group (all P <0.05). The median progression-free survival time was significantly longer in the study group than in the control group (P <0.05). Conclusion SIB can improve the objective response rate, disease control rate and 1-year survival rate in patients with brain metastases of lung cancer, and prolong the median survival time.