由于天然抗体具有结合异种内皮细胞,补体激活和内皮细胞激活的作用,导致了不同种之间的异种移植物仅存活几分钟。从正常供血者提取的静注用多克隆免疫球蛋白(IVIG)已经证明对各种抗体介导的疾病有效,且其含针对大量疾病相关的和天然的抗独特型抗体。作者已经证明通过注射IVIG延迟豚鼠心脏植入大鼠的排斥反应。在此还证明了IVIG能抑制异种反应性大鼠IgG抗体结合豚鼠内皮细胞。这种抑制很可能因为在 Since natural antibodies have the effect of binding to xenogeneic endothelial cells, complement activation and endothelial cell activation, it results in only a few minutes of xenograft survival between different species. Intravenous polyclonal immunoglobulins (IVIGs) extracted from normal blood donors have been shown to be effective against a variety of antibody-mediated diseases and are directed against a number of disease-associated and natural anti-idiotypic antibodies. The authors have demonstrated delayed rejection of the guinea pig heart implanted rat by injection of IVIG. It has also been demonstrated here that IVIG inhibits xenoreactive rat IgG antibodies from binding to guinea pig endothelial cells. This inhibition is likely because of