原来常采用利尿药和β－阻滞剂来治疗高血压。自从有了血管紧张素转换酶抑制剂（ＡＣＥ—Ⅰ）和钙游子拮抗剂（ＣＡ）后，以此替换上述药物治疗高血压，费用增加了不少，临床上都未能见到冠心病的高危情况有所降低。如遇对利尿药和β—阻滞剂有反指征时才考虑换用，是较为合适的。 The original use of diuretics and β-blockers to treat high blood pressure. Since angiotensin converting enzyme inhibitors (ACE-I) and calcium antagonists (CA) have been used to replace the above drugs for the treatment of hypertension, the cost has increased a lot, and have not been clinically seen coronary heart disease High-risk situations have declined. In case of anti-diuretics and β-blockers anti-indications only consider switching, is more appropriate.