创伤和出血后细胞免疫功能有明显紊乱,从严重损伤后不到1小时的病人身上采集的外周血单核细胞(PBMCs)的有丝分裂增殖减少50％以上,白细胞介素2(IL-2)产生减少90％以上。出血引起的淋巴细胞的产生被抑制可能是由于失血后血清中存在一种因子,该因子已部分被纯化,似乎是一种蛋白质, Significant disturbances in cellular immunity following trauma and hemorrhage have been observed, with more than 50% reduction in mitogenic proliferation of peripheral blood mononuclear cells (PBMCs) collected from patients less than one hour after severe injury, and production of interleukin 2 (IL-2) Reduce by 90% or more. The inhibition of bleeding-induced lymphocyte production may be due to the presence of a factor in serum after blood loss that has been partially purified and appears to be a protein,