美国Stampfer等人于1976年曾对119061名年龄为30～35岁的妇女进行研究,了解有关应用口服避孕药对发生各种心血管疾病的危险性有无影响的问题。这些妇女既往均无冠状动脉疾病及卒中等病史。连续追踪观察8年,其中有484 096人-年从未有应用过口服避孕药,415 488人-年既往曾应用过口服避孕药,22 376人-年则有近期应用口服避孕药。结果观察到在此期间发生严重冠状动脉疾病的新病例485例,其中非致命性心肌梗塞380例,因冠状动脉疾病致死者 In 1976, Stampfer et al. Conducted a study of 119061 women aged 30-35 years to find out whether the use of oral contraceptives had any effect on the risk of various cardiovascular diseases. None of the women had previous history of coronary artery disease and stroke. Eight consecutive years of follow-up were observed, of whom 484,096 were reported - no oral contraceptive has ever been used and 415,488 people have had oral contraceptives and 22,376 had been used in the past year. Oral contraceptives have recently been used. Results A total of 485 new cases of severe coronary artery disease were observed during this period, of which 380 were non-fatal myocardial infarction and those who died of coronary artery disease