论文部分内容阅读
自发性细菌性腹膜炎(SBP)是肝硬化腹水住院患氨者的严重并发症,从感染腹水中常分离出能产生β内酰胺酶的革兰氏阴性菌株。棒酸(clavulanic acid)与羟苄青霉素合用时,能杀灭产生β内酰胺酶的耐药菌株。作者前瞻性地评价羟氨苄青霉素与棒酸联合治疗肝硬化患者SBP的效果及短期(2周)和(?)期(1年)预后,并对两药在患者血清和腹水中的药代动力学进行了探索。所有腹水患者临床表现提示SBP者均作腹腔穿刺。腹水离心后作常规检查和需氧及厌氧菌培养。另将10 ml腹水注入100 ml液态培养基后直接培养,并用
Spontaneous bacterial peritonitis (SBP) is a serious complication of hospitalization for patients with cirrhosis with ascites, and gram-negative strains that produce beta-lactamase are often isolated from infected ascites. Clavulanic acid, when used in combination with ampicillin, will kill resistant strains that produce beta-lactamase. The prospective evaluation of amoxicillin combined with clavulanic acid in the treatment of patients with cirrhosis of SBP and short-term (2 weeks) and (?) (1) prognosis, and two drugs in patients with serum and ascites pharmacokinetics Learning to explore. The clinical manifestations of all patients with ascites prompted SBP were for abdominal puncture. Ascites for routine examination after centrifugation and aerobic and anaerobic culture. The other 10 ml of ascites into 100 ml of liquid medium after direct culture, and use