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本文研究此药对血凝系统、抗凝系统、纤溶系统和血小板计数及其功能的影响。结果表明,用药一年以上,Ⅶ:C 和ⅦR:Ag 增高;PT 时间缩短,在统计学上均有意义;用药三年以上,Ⅸ:C 活性增高;用药6个月时,RVVT 时间延长,纤维蛋白原下降;随后回到原来水平。用该避孕药期间,抗凝血酶Ⅲ活性和抗原性无变化,注射该避孕药三年以上时,血浆素原和纤维蛋白原溶解活性增高,在统计学上有意义。用药一年以上时,ADP 诱导的血小板聚集加强。
This article studies the effect of this drug on the coagulation system, anticoagulation system, fibrinolysis system and platelet count and its function. The results showed that more than one year after treatment, Ⅶ: C and Ⅶ R: Ag increased; PT decreased, which was statistically significant; medication more than three years, Ⅸ: C activity increased; medication 6 months, RVVT prolonged, Fibrinogen decreased; then back to the original level. During this contraceptive use, there was no change in antithrombin III activity and antigenicity. When the contraceptive was injected for more than three years, plasma pro-fibrinogen and fibrinogen lytic activity increased statistically significant. ADP-induced platelet aggregation was enhanced at more than one year of treatment.