论文部分内容阅读
树突状细胞(DC)是专职的抗原提呈细胞,能浸润很多种肿瘤,并获取、处理、并提呈肿瘤相关抗原给T细胞,诱导特异性抗肿瘤免疫反应。但在肿瘤微环境中,存在一系列瘤源性抑制因子,这些因子对DC的发育成熟都有直接或间接的抑制作用,癌症患者体内外周血循环中的DC和浸润到肿瘤中的DC都受到这种作用的影响而存在表型和功能的缺陷。已经证明,导致DC缺陷的几种肿瘤来源的因子有VEGF、IL-6、IL-10、M-CSF等。进一步深入了解DC分化缺陷的主要因素有助于发展更有效的抗癌免疫治疗策略。
Dendritic cells (DCs) are specialized antigen-presenting cells that infiltrate many types of tumors and acquire, process, and present tumor-associated antigens to T cells to induce specific anti-tumor immune responses. However, in the tumor microenvironment, there are a series of tumor-derived inhibitory factors that directly or indirectly inhibit the development of DC. Both DC in the peripheral blood and DCs infiltrating into the tumor in cancer patients are affected by this The role of the existence of phenotypic and functional defects. Several tumor-derived factors that cause DC defects have been demonstrated to be VEGF, IL-6, IL-10, M-CSF and the like. Further understanding of the major factors that contribute to the dedication of DCs contributes to the development of more effective anti-cancer immunotherapy strategies.